初潮年龄与成年后非酒精性脂肪性肝病患病风
论著/OriginalArticle
JournalofDiabetes9()53-60
初潮年龄与成年后非酒精性脂肪性肝病患病风险相关
Ageatmenarcheisassociatedwiththeprevalenceofnonalcoholicfattyliverdiseaselaterinlife
JieliLU,1,2JieZHANG,3RuiDU,1,2TiangeWANG,1,2MinXU,1,2YuXU,1,2WeiqingWANG,1,2,3YufangBI,1,2DonghuiLI,4YuhongCHEN1,2,3andGuangNING1,2,3
1KeyLaboratoryforEndocrineandMetabolicDiseasesofMinistryofHealth,Rui-JinHospital,ShanghaiJiao-TongUniversitySchoolofMedicine,E-InstituteofShanghaiUniversities,Shanghai,China,2DepartmentofEndocrineandMetabolicDiseases,ShanghaiClinicalCenterforEndocrineandMetabolicDiseases,ShanghaiInstituteofEndocrineandMetabolicDiseases,RuiJinHospital,Shanghai,China,3DepartmentofEndocrineandMetabolicDiseases,RuijinHospitalNorth,ShanghaiJiaotongUniversitySchoolofMedicine,Shanghai,China,and4DepartmentofGastrointestinalMedicalOncology,TheUniversityofTexasMDAndersonCancerCenter,Houston,TexasUSA
摘要
背景：本研究旨在分析初潮年龄与非酒精性脂肪性肝病（non-alcoholicfattyliverdisease，NAFLD）患病风险相关性。
方法：我们在该横断面研究中纳入了名绝经后中国女性，分析了初潮年龄、肥胖、胰岛素抵抗等因素与NAFLD患病风险的相关性。根据肝脏超声结果诊断NAFLD，初潮年龄信息由调查人员通过调查问卷形式进行采集。
结果：与初潮年龄在15-18岁之间以及大于18岁的绝经后女性相比，初潮年龄小于15岁者的超重/肥胖、胰岛素抵抗以及NAFLD患病率均显著升高。Logistic回归分析显示，在校正年龄后，初潮年龄较早的女性超重/肥胖、胰岛素抵抗以及NAFLD患病风险显著升高，而初潮年龄较晚的女性则表现出较弱但显著减低的NAFLD患病风险。然而，在进一步校正了目前体重指数（bodymassindex，BMI）或者胰岛素抵抗的稳态模型评价（homeostasismodelassessmentofinsulinresistance，HOMA-IR）后，初潮年龄较晚对于NAFLD患病保护作用减弱。随着初潮年龄的增长，NAFLD患病风险呈现显著下降趋势（年龄校正Ptrend0.；多元校正Ptrend0.；多元校正+目前体重指数校正Ptrend=0.03；多元校正+HOMA-IRPtrend=0.06）。
结论：初潮年龄与成年后NAFLD患病风险显著相关，且独立于BMI及胰岛素抵抗状态。
关键词：初潮年龄，胰岛素抵抗，非酒精性脂肪性肝病，肥胖
英文摘要：
Background
Theaimofthepresentstudywastoinvestigatewhetherageatmenarcheisassociatedwithnon-alcoholicfattyliverdisease(NAFLD)laterinlife.
Methods
Theassociationbetweenageatmenarcheandobesity,insulinresistance,andNAFLDaftermenopausewasinvestigatedinacross-sectionalstudyofpostmenopausalChinesewomen;NAFLDwasdiagnosedbyhepaticultrasoundandinformationregardingageatmenarchewascollectedusinganinterviewer-administeredquestionnaire.
Results
Womenwithageatmenarche15?yearshadhigherprevalenceofoverweight/obesity,insulinresistance,andNAFLD治疗白癜风最安全的方法北京哪里有专业治疗白癜风的医院
