亚临床2型糖尿病不是ALS的预测因素
MuscleNerve.Apr21.doi:10./mus..
Pre-morbidtype2diabetesmellitusisnotaprognosticfactorinALS.
PaganoniS1,HymanT,ShuiA,AllredP,HarmsM,LiuJ,MaragakisN,SchoenfeldD,YuH,AtassiN,CudkowiczM,MillerTM.
Authorinformation
1HarvardMedicalSchool,NeurologicalClinicalResearchInstitute(NCRI),MassachusettsGeneralHospital,Boston,MA;HarvardMedicalSchool,DepartmentofPhysicalMedicineandRehabilitation,SpauldingRehabilitationHospital,Boston,MA;VAHealthcareSystem,Boston,MA.
Abstract
OBJECTIVE:Todeterminewhetherahistoryofpre-morbidtype2diabetesmellitus(DM2)isaprognosticfactorinamyotrophiclateralsclerosis(ALS).
METHODS:TherelationshipbetweenDM2andsurvivalwasanalyzedinastudypopulationconsistingof1,participantsfrom6clinicaltrials.
RESULTS:Survivaldidnotdifferbydiabetesstatus(Log-RankTest,P=0.98)butdiddifferbybodymassindex(BMI)(Log-RankTest,P=0.).Inmultivariateanalysis,therewasnosignificantassociationbetweendiabetesandsurvival(P=0.18),buttheriskofreachingasurvivalendpointdecreasedby4%foreachunitincreaseinbaselineBMI(HR0.96,95%CI0.94-0.99,P=0.).DM2waslessprevalentamongALSclinicaltrialparticipantsthanpredicted.
CONCLUSIONS:Ahistoryofpre-morbidDM2isnotanindependentprognosticfactorinALSclinicaltrialdatabases.ThelowDM2prevalencerateshouldbeexaminedinalarge,prospectivestudytodeterminewhetherDM2affectsALSrisk.Thisarticleisprotectedbycopyright.Allrightsreserved.
?WileyPeriodicals,Inc.
KEYWORDS:ALS;BMI;diabetes;prognosis;survival
PMID:[PubMed-assuppliedbypublisher]
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